Endocrine Abstracts

Purpose: Agouti-related protein (AgRP) is known as an orexigenic neuropeptide which is expressed in the hypothalamic arcuate nucleus. It’s possible AgRP is an important molecule in glucocorticoid (GC) induced obesity (e.g. Cushing syndrome), because GC positively regulate hypothalamic AgRP. To clarify the role of AgRP in GC-induced obesity, we investigate here the effect of GC on AgRP deficient mice.Methods: Male wild-type littermates (n=20...

Purpose: Glucocorticoid is one of the key hormones that regulates energy balance. Glucocorticoid excess induce hyperphagia and obesity (e.g. Cushing syndrome), however, its mechanisms are not fully elucidated. On the other hand, Agouti-related protein (AgRP) is known as an orexigenic neuropeptide, which is expressed in the hypothalamic arcuate nucleus. To clarify the role of Agouti-related protein (AgRP) in glucocorticoid-induced obesity, we investigate here the effect of gluc...